KMID : 1130620070030020079
|
|
Journal of Clinical Neurology 2007 Volume.3 No. 2 p.79 ~ p.81
|
|
Use of the Putamen/Caudate Volume Ratio for Early Differentiation between Parkinsonian Variant of Multiple System Atrophy and Parkinson Disease
|
|
Shin Ha-Young
Sohn Young-Ho Yang Jae-Hoon Kang Suk-Yun Kim Hyun-Sook Lee Myung-Sik
|
|
Abstract
|
|
|
Background and purpose: Neuropathological studies have demonstrated that multiple system atrophy (MSA) produces selective atrophy of the putamen with sparing of the caudate nucleus, while both structures are spared in idiopathic Parkinson¡¯s disease (PD). In this study we evaluated the clinical efficacy of using putaminal atrophy in brain MRI to differentiate MSA and PD.
Methods: We measured the putamen/caudate volume ratio on brain MRI in 24 patients with MSA and 21 patients with PD. Two clinicians who were blinded to the patients¡¯ diagnoses and to each other¡¯s assessments measured the volume ratio using a computer program.
Results: The measured volume ratios of the two investigators were highly correlated (r=0.72, p<0.0001). The volume ratio was significantly lower in MSA (1.29¡¾0.28) than PD (1.91¡¾0.29, p<0.0001). Setting an arbitrary cutoff ratio of 1.6 resulted in about 90% of patients with MSA falling into the group with a lower ratio, whereas more than 80% of patients with PD belonged to the other group.
Conclusions: The present results demonstrate that putaminal atrophy in MSA as measured on brain MRI represents an effective tool for differentiating MSA from PD
|
|
KEYWORD
|
|
Parkinson¡¯s Disease, Multiple System Atrophy, Putamen, Brain MRI
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|